Our Favorite Supplement for PCOS: Ovasitol w/ Dr. Mark Ratner!

What is Ovasitol and how does it help women with PCOS? The inventor of Ovasitol, Dr. Mark Ratner, joins us to discuss the benefits of Ovasitol!

Were you prescribed Metformin by your doctor? Dr. Mark Ratner explains the difference between Metformin and natural inositol supplements like Ovasitol as well as covering studies confirming the effectiveness of inositol supplements compared to Metformin!

What effect does Ovasitol have on helping pregnancy and the risk of gestational diabetes for women with PCOS? Dr. Mark Ratner explains the role insulin resistance plays in women with PCOS and how an inositol supplement can be vital.

We also pulled your questions from Instagram and asked Dr. Mark Ratner on the episode, tune in to hear all your most popular questions about Ovasitol answered!

Ovasitol Packets: 15% OFF prc code 292660 (bit.ly/Ovasitol)

Join us in The Cysterhood, a community of women learning how to manage PCOS & lose weight, Gluten and Dairy Free! (bit.ly/The-Cysterhood-Membership)

Pique Tea: 5% off code TheCysterhood (bit.ly/PiqueTeaPCOS)

PCOS Friendly CBD: 10% OFF code TheCysterhood (bit.ly/CBDpcos)

While Tallene is a Registered Dietitian and Sirak a Personal Trainer, this podcast provides general information about PCOS. It is not meant to serve as fitness, nutrition or medical advice related to your individual needs. If you have questions, please talk to a medical professional. For our full privacy policy, please click on the following link: (bit.ly/PCOSPrivacyPolicy)

Full Episode transcript:

All right, babe. Let’s take a moment to correct our posture. Take a deep breath and have some pure spectrum CBD. Sure. Hey sisters CBD can help with acne inflammation, anxiety asleep, and so many other PCOS symptoms. I personally take it throughout the day to help keep my stress hormones nice and low. Not to mention I sleep like a baby every night and I don’t wake up fatigue At all.

Now open your mouth, please. So I can give you a serving. Now, hold it for 60 seconds. Head over to pure spectrum cbd.com and use the code, the sisterhood one word for 10% off. Can I stop now? Nope. You got 30 more seconds. Did you hear about that sister who took Obasi tall and finally got her period after a year of not having Incredible.

I see those kinds of messages on Instagram a lot. How does that even happen? Versatile helps with healing, insulin resistance, a common root issue that most Pecos sisters have and by targeting insulin resistance, we’re seeing sisters kick those crazy cravings. Finally regulate their periods opulate and improve their ed quality. Each packet of opacities has a 40 to one ratio of myo-inositol.

This ratio is similar to the ratio that should be found in the body. But with women like me who have S this ratio is often imbalanced. So taking a bus tall can be super effective in treating insulin resistance, starting from the root of the issue. So awesome. It tastes like nothing. So just warn me when you put it in a cup,

so I don’t drink it. You got it. BU check out the link in the description to get 15% off your order. What’s that this is a refreshing mint tea on ice. I drink it daily because studies show that it can help reduce elevated testosterone. And as a result, help me manage PCs symptoms like acne, mood, hair loss. My other favorite flavor is there electric tumeric,

which helps with immunity while providing anti-inflammatory support. Great for PCOS. It’s also blended with ginger, which is great for digestion and cinnamon to help support healthy blood sugar and combat cravings. I don’t see a teabag in it. That’s right. Peak delivers concentrated antioxidants and plant nutrients that are extracted with cold brew crystallization. So I don’t need a teabag. I can easily just pour it into hot or cold water.

There’s no prep or brewing necessary. And for something I plan to consume every day, I want to ensure that it’s pure two studies show that those other fancy teabags leak billions of microplastics into your tea peak has been triple toxin screened for pesticides, heavy metals and toxic mold. They make it super accessible to get effective and purity. Wow, that’s amazing. Let me try some shit Head over to peak t.com

forward slash sister spelled P I Q U E T E a and use our code, the sisterhood one word to get 5% off your first order. Welcome to a sister on her, Mr. A podcast, where we show you the real behind the scenes of how we bounced the PCRs lifestyle in our marriage, gluten and dairy free. I’m telling your fellow sister and registered dietician and I’m Seadog husband,

engineer, and PCO personal trainer. We’re going to make peace. You as a little less overwhelming and a lot more fun. Here’s to another episode of the podcast today, we have a very special guest and he is the founder of acetone, Dr. Marc Ratner. He is a physician ologists and works with one of the largest for 30 practices in the United States.

He is a founding physician of and Sebastopol and serves as the chief science officer of the company. Thank you, Marc Ratner for joining us today. My pleasure. There are so many sisters listening right now who are taking Avast natal and they are loving it. We always hear such wonderful reviews. So I just want to say thank you on behalf of all of the women with PCOS who love opacity that get our periods back and regulate so many S symptoms.

Great to hear. Yeah. One of them being utopian, you were taking about salt with your, when you were first diagnosed with PCOS. And so, yeah, it took me a while to come across it, which was interesting. Someone had to show it to me, a doctor didn’t actually tell me about it. And my friend showed me cause she had PCOS too.

And it was so life-changing and I actually, I can’t believe that it’s not one of the first things that doctors recommend when we get diagnosed with PCLs, which launches into my first question. Why do you feel like doctors aren’t recommending and also taller Obasi tall? You know, when people are, when sisters are first diagnosed with PCLs. So the, the story behind in NASSA talls and the potential benefit in PCO S women is a really interesting one and it starts like a little bit more than 20 years ago.

And it actually starts in the United States. There was a company in Virginia that tried to produce a pharmaceutical drug, which was de Cairo in ASA tall. It was basically just the Cairo and NASA tall, and they published a study. I think it was 1999 in the new England journal of medicine using for women with PCOS, but they used a relatively low dose to make a long story short.

That company then tried to develop the product by using higher and higher doses. And what they discovered was that if you give women with DCOS high doses of DeCaro in NASSA tall, it does no good. And in fact, it’s harmful. And so they lost interest in it. And for a number of years, it went nowhere. But then in Italy and other parts of Europe,

scientists began to look at other forms of a not-so-subtle, particularly myo-inositol. And it was really the Europeans who then kind of took the ball and ran with it, so to speak. Okay. All of the basic science, all the clinical studies that were published over the last 15 years were in European journals. And there’s a certain attitude. I don’t want to speak ill of my fellow physicians here in the States,

but there’s a certain attitude, which some people joke lean we’ll call NIH syndrome, which means not invented here. Okay. Oh My gosh. Okay. Okay. Well, I mean, it’s a facetious joke, but I mean, the point is that docs in the United States, they don’t necessarily read the journals that get published in Europe. Okay. And so about four or five years ago,

maybe five or six years ago, we were following the literature in Europe and we realized that there was a tremendous amount of evidence piling up about the benefits of using myo-inositol and DeCaro and us at all together for PCO S not only for fertility, restoring oscillation and improving fertility, but also for dealing with all of the metabolic issues that women with PCOS have. And so we produced this product.

We created Obasi tall. Okay. Maybe six years ago now. And then we really had a job to do, because as you just pointed out, the doctors that we were speaking to, we would go to fertility conferences. We have a Salesforce that calls on doctor’s offices around the country, and we would get a lot of blank looks. Yeah. Okay.

And so the answer to your question is it’s been a very slow process for us to educate physicians in the United States about the science and about what the studies show. And in fact, a couple of years after maybe a year after we launched the product, we were put in touch with one of the premier PCO S researchers here in the United States. And I had a long phone call with this guy,

this doctor, professor fertility, professor who’s, who’s published some of the biggest PCO studies in the United States. What’s his name? Well, Its name is Rick. Legrow Dr. Richard Legrow he’s at Penn state Hershey. Okay. You mentioned he’s a big researcher in PCs. I’ve just never heard of any researchers and pieces. I was curious to know who you was.

I don’t know, Rick Rick will grow amongst reproductive endocrinologists. Dr. Lee grow is widely known and very widely respected. And so he and I had this conversation. I shared a lot of the published literature from Europe with him. I was wondering whether he would be interested in trying to do a clinical trial here in the United States, because we were thinking maybe if we could do a trial here in the United States,

get it published in a us journal. Us doctors would sit up and take notice. Yeah. And his first reaction was, I’m not really familiar with any of this. And, you know, I mean, he had kind of a, sort of bigger fish to fry as they say, right. But we kept talking and to his credit, he really immersed himself in the European literature.

And ultimately we decided, okay, he decided and asked for our help, I’m going to try and get a funding grant. I’m going to try and get a research grant from the NIH, the national institutes of health to study. And NASSA talls in PCOS. And it took us, took him two years of work. And we helped with designing this study,

we help with we’re producing the intervention. The NASSA 12 product that is being used. We’re producing that along with placebo. And that study is now underway at Penn state Hershey fund funded by the U S national institutes of health. So yeah, we’re making a lot of progress more and more docs in the United States are becoming familiar with the NASSA talls. And there’s,

I think an increasing interest in sort of taking a multidisciplinary approach, one of the problems. And I, you know, I know I’m preaching to the choir here. One of the problems that PCO S patients face is they fall through the cracks. Okay. The reproductive endocrinologists, you know, the doctors that run the IVF programs, their focus is fertility.

Their focus is getting your pregnant, but you know, if it’s a high school girl, if there’s, you know, a young woman in high school or college student, she could maybe not even remotely thinking about getting pregnant, she just wants to deal with all the other effects of PCLs. And so not every fertility practice is sort of equipped and that interested,

even in focusing on helping those individuals, it’s not an easy area to work in. I mean, it needs a multidisciplinary approach. You need, you need an endocrinologist, you know, a endocrinologist, you need a dietician, okay. You might need people doing aesthetics stuff like hair removal, dermatology. I mean, you know, you might need a multidisciplinary approach.

And, and so we’re starting to see that happen in some fertility programs around the country. And we’re starting to see it a little bit in some just sort of OB GYN practices, you know, sort of just standard OB GYN practices, but it’s still, I think, largely an unmet need. Yeah. It’s super important. I completely agree that having a multidisciplinary approach will help treat PCLs more effectively.

And, you know, women with PSUs do fall through the cracks, oftentimes going misdiagnosed or simply ignored and given birth control until they decide to have babies. So yeah, there aren’t enough, you know, treatment people treating PCs in an interdisciplinary way, but I’m happy to hear that it’s improving at least, you know, and with social media too, people can just hop on Instagram and find us or whoever to help them manage PCOS naturally.

Sure. In like, in addition to going to the doctor’s office. Okay. And then could you explain what is and why it’s important that the ratio of the 42, one myo and DeCaro, and also tall. Okay. I’ll, I’m going to get started on it, But you’re going to have to jump in and just say, okay, stop,

stop, stop. Because we’re going to quickly run out of time. So in NASA, talls are what we call sugar alcohols. So in the same family, as sort of a xylitol mannitol sorbitol, there’s actually nine different Inacio talls. They are what we call stereo isomers. They all have a slightly different configuration of the molecular bonds that hold the molecule together.

Two of those nine myo-inositol and DeCaro in us at all are very important in our bodies, insulin functioning. They serve as what we call the second messengers for the insulin hormone. So the pancreas releases insulin when the sugar level in the blood goes up after a meal, let’s say, and then when insulin binds to the surface of the cell, as it binds the receptor that it binds to has to release what we call second messengers into the cell that tells the cell what to do.

Okay. And it turns out that those second messengers are myo-inositol and de Cairo us home. Those two compounds are very important for the F for the normal functioning of insulin in our body. Insulin is what allows ourselves to take the sugar up from the bloodstream, right? And process it, burn it for energy, or maybe sometimes even store it as glycogen for later use.

If you can’t take in the sugar, if your cells can’t take in the sugar, the blood sugar level in your blood goes up and up and up and up, okay. We call that hyperglycemia. Okay. Now, when the problem is insulin resistance, what’s going on is that the second messengers are not being released properly. And as a result, you can’t take the sugar in.

So the sugar builds up in the blood and the pancreas, which is what’s making the insulin. The pancreas sees all that extra sugar in the blood and says, Ooh, we need more insulin. So the pancreas then releases extra insulin into the blood because the insulin is not working like it’s supposed to. The second messengers are not being released as a result.

Patients who have insulin resistance, they have elevated blood sugar and they also have elevated blood insulin. So this is what happens in insulin resistance. It’s also what happens in type two diabetes and PCO S and gestational diabetes. You know, women who get diabetes late in their pregnancy, all of those things have as the underlying cause what we call insulin resistance, meaning this plenty of insulin,

it just doesn’t work. Right? Because those second messengers are not being released properly. And so when we say they’re not being released properly, what it really boils down to is the ratio between myo and de Cairo in NASSA tall, the body’s normal ratio is 40 to one 40 times, 40 myo, and one DeCaro so much more mild than de Cairo.

Right. And, and sorry. It’s okay. The guests get the second guest on the podcast, The, the joys of the pandemic right. Working. He could, he could start again too. Anyway. Okay. So the point is what happens in insulin resistance and in PCLs is that the ratio gets out of whack. Okay. And our goal in supplementing an Avast tol let’s say is to restore that 40 to one ratio,

which allows insulin sensitivity to improve, which means insulin resistance decreases. Okay. Yeah. That was great. I love that explanation because a lot of times we explain to the women with PCOS that the reason why basketball is such a great option, it has a 40 to one ratio, but the way you explain it, there is yeah. Scientific, overarching explanation.

Cause I know a lot of women with PCOS are asking, should I just take, can I just take inositol instead of Avast at all? And we always say that opacity has the 40 to one ratio that the ratio in your body and works more effectively. Yeah. That’s exactly correct. Yeah. Yep. All right. I’m glad we were correct. Yeah.

And what effect does Avastin Tal have on helping with pregnancy and the risk of gestational diabetes for whom with PCOS? So this a great question. The point here is that some women might think, Oh, well, if I’m trying to get pregnant and I take a Vasa tall and it restores my ovulation and I get pregnant, I can stop taking a Vasa tool.

But the point is that women with PCOS have triple the risk of gestational diabetes. And it’s been shown that if you stay on an insulin resistance approach, either with Metformin, which is a little bit riskier or Avast tol you reduce your risk of gestational diabetes by about 50% cuts it in half. So it’s a, it’s a good thing to do. Stay on it during the pregnancy.

So many women with PCOS, aren’t looking to get pregnant and they are all looking for something to help them with getting their periods back, regulating cravings, all of the wonderful things that that Avastin has done for me in many sisters. Could you explain the mechanism behind that behind how it helps with cravings and how it helps with our periods? Well, it’s two separate things,

restoring ovulation, restoring your periods, making them more regular that has to do with balancing out the estrogen and progesterone and testosterone in your system. The other thing that we know is that DeCaro, and NASSA tol actually acts as the second messenger for FSH, follicle, stimulating hormone, which is what helps the ovary to produce an egg. So it’s basically normalizing your hormone levels by reducing the insulin resistance.

Okay. The cravings, I can’t speak to, I, I, you know, I don’t have an answer. We do know that under certain circumstances in ASA talls can reduce anxiety. There’s some studies that show it can benefit women or anybody with depression, but those typically have much higher doses, you know, like 16, 18 grams per day. But we know that it actually can work in the brain as well.

But beyond that, I don’t think I I’ve got a good explanation for why that does happen. Yeah. I think I’m thinking that it’s because of treating the insulin resistance, like the less insulin floating around in your bloodstream, the less cravings you have for That’s certainly a good, a good possibility for sure. Yeah. All right. Before We launch into the questions that women with PCOS asked me on Instagram task,

you I’m wondering, hypothetically speaking, if SciTech accidentally drank, Oh, Basset doll, what would happen Really day? She’s drinking it it’s clear. Sometimes it’s like, it’s like barely tasteable. So I ended up drinking like half the Coke. Is this okay? It’s absolutely fine. Yeah. Yeah. This isn’t something, this isn’t some foreign substance at the,

ER, the average us diet contains about a thousand milligrams of an ASA tol per day. Okay. It’s mostly in, in fruits and vegetables. So we’re getting some NASSA talls in our diet. No worries there. Okay. That’s good to know. So I picked up a few questions on Instagram from our ladies with PCOS and they are asking, why was it decided to make opacity a powder,

not a pill? Well, convenience is the primary issue to get four grams per day into pill form. You’d be talking about capsules. That would be very large. And you’d probably need about between six and eight capsules per day. Wow. And, and so you’d need to take three or four in the morning and three or four in the evening and you absolutely have to drink a good eight ounces of water to get that many capsules down.

Yeah. So it, it doesn’t really make a difference in terms of absorption or anything like that. It was really more a convenience issue in terms of people just, you know, pick your poison. Do you like to take a handful of pills morning and evening, or just take a packet as you, as you pointed out, it’s totally clear. Colorless,

odorless, tasteless, a little bit sweet. A little bit of sweetness. Yeah. Because it’s a sugar alcohol, I, you know, a packet has like two calories. I mean, it’s, you know, really it’s nothing, nothing minimal caloric content. So that’s why, yeah. If that makes sense. I mean, I would not be very drawn towards a supplement that I have to take eight times a day versus just worrying about water Twice,

twice a day, but you know, four pounds, eight pills. Yeah. Yeah. I mean, yeah. Twice a day, four pills each time, right? Yeah. No, that sounds like a lot. Yeah. Okay. Great idea. The powder. Is it still helpful to women with PCOS who don’t have insulin resistance? That’s a good question.

The answer is we don’t know. And the reason I say that is because in certain settings it appears to be like IVF. Okay. We know that Inacio tall supplementation, even in non PCOS, women improves egg quality. Okay. Now, in order to do a study where you look at the most important endpoint in fertility, and what’s the most important endpoint pregnancy live birth,

right. In order to do a study that would use those endpoints, it’s got to be a gigantic study. You’ve got to enroll hundreds and hundreds of couples. Okay. And that kind of a study is going to cost a fortune. Okay. Which is why it has to be funded by something like the NIH. And so the point is that the studies that have been done in non PCO S women with the NASSA tallest,

they tend to be in a model like an IVF setting. Okay. Will it help in a natural conception setting? No one’s ever studied that, but we do know that in an IVF setting where they actually extract the eggs and they look at the eggs under a microscope and they can see the quality of the eggs, are they, you know, are they high quality,

eggs, low quality eggs. They look under the microscope and they can grade the eggs in an IVF cycle. They know that in NASA tool use improves air quality, even non-kin cos And that women with PCLs struggled to articulate and have a healthy egg quality in general, you know, whether you’re insulin resistant or not most women with PCs aren’t oscillating, I would deduce that taking a basketball can improve your oblation and in turn periods.

Would you agree? Yeah. Yeah. Okay. So is it okay to take with birth control for women who we should also admit those are the two most common questions? Yeah, absolutely. In terms of insulin resistance, birth control pills do, do not improve that. Okay. One of the things that happens with PCLs women is that the excess insulin,

when you’re insulin resistant and the amount of insulin in your blood is chronically too high. Okay. All that excess insulin makes the ovary produce testosterone and, you know, testosterone is male hormone. Right? Okay. Now women have mostly estrogen and a little bit of testosterone, man, it’s the opposite. They have mostly testosterone, but they have a little bit of estrogen as well.

But in women, if the testosterone level gets pushed up too high, which is what happens in PCLs and you get all of those metabolic type of, you know, skin issues and hair issues, those things, you know, the birth control pills can help with the testosterone issue. Okay. But it won’t help with the underlying insulin resistance. And so things like those cravings you were talking about or possibly weight,

and obviously, you know, for fertility, it’s, it’s not possible to get pregnant when you’re trying to control your PCOS with birth control pills. So, right, Right. And what about Metformin? Because we’ve read that in ASA, tol can work just as effectively as Metformin studies have shown can cannabis to be taken with Metformin. And also like, can we speak upon some sisters who have actually swapped over to opacity tall from Metformin because of the side effects of Metformin?

Yeah. So a great question. We have a number of studies that have looked at Metformin and in ASA talls, head to head in terms of metabolic outcomes, a hand, a handful of studies that have also looked at fertility in an IVF setting. Okay. And they appear to be just as good as one another. Okay. The main difference between the two,

when you look at these studies is that the adverse events, the side effects from Metformin are five times higher, literally five times higher. Now mid form is not a bad drug. You know, I don’t want to, I don’t want to bad mouth Metformin. There’s actually some evidence about Metformin being a longevity drug. And there’s actually a couple of big studies that are ongoing right now because it has to do with and sort of extending the lifespan of cells that would otherwise die.

And so Metformin, except for its tolerability issue, not a bad drug, it’s just that in the Pecos setting, it appears as if an ASA, talls and 40 to one ratio like Lavasa tall is as good in terms of restoring insulin sensitivity and in terms of restoring ovulation and reducing testosterone. So can you take the two together? Yeah. You can.

It’s probably not going to help you much. There’s are a couple of studies. One recently published that looked at in NASSA tall alone versus a NASSA tall plus Metformin. No combine the two. We’re just doing NASA all alone. No real difference. Oh, wow. Wow. No real difference. Yeah. So yeah. One last question. Can we take,

or should we take Avastin for more than three months? Cause I know it comes in a three month supply. Yeah. So the, the answer to that question is not, not really, it depends, but the answer really is this, why did we give it a, put it in a three month supply? Because most of the studies show that a three month course of NASSA supplementation is probably the minimum reasonable trial to restore ovulation.

You can’t take it for a month and say, Oh, I still haven’t gotten my period. This isn’t working. Most of the studies say, give it three months in terms of the metabolic issues, in terms of the hormone issues like testosterone issues and insulin resistance, you may need to see six months before it may need to try it for six months before you start to see skin and hair issues starting to respond fully.

So that’s why we did three months, you know? And you’ll, if you go on Amazon, it’s really kind of, I guess it’s sad, but not surprising if you go on Amazon, the biggest selling product, I don’t even remember the name of it. It costs like, you know, 24 95. Yeah. But if you really read the fine print,

what they’re selling you is a 15 day supply. I know your story of, of what’s essentially, if they say take 2000 a day, now the studies all basically show you need 4,000 a day. Okay. But there, there are products that are being sold on Amazon where they say, okay, our dose is 2000 a day and this is a 30 day supply.

But in reality, it’s a 15 day supply. If you take 4,000 and it’s 24 95. So if you really want to try it for three months to give it a fair chance to work, that’s a lot of money. Nevertheless, people say, Oh, it’s only 24 95. I’ll buy that. So yeah, it’s, there’s a lot of a misdirection.

Yeah. We get that a lot. Because many times people will be like, understandingly. There’ll be like, Oh, basketball is too expensive. Can I get this instead? Like what you were talking about, they don’t realize what they’re trying to get instead is only like a one month supply or in many cases, only half of that. And they usually need to take it for three months.

It’s going to be more expensive in the long run. Yeah. I think the message that has to be made clear is you really want to give this three months to decide whether it’s helping or not. And you need to take 4,000 per day, 2000 in the morning and 2000 in the evening. Yeah. And depending on how severe the PCR symptoms are too,

you know, you I’ve seen people take it for a whole year and they’ve seen great results because they took it for a whole year. And not just the three months because their PCLs was more severe. They were changing their diet and lifestyle at the same time. And it just took more time and patience and you know, to get all those symptoms to reverse too,

and getting used to taking it twice a day consistently takes Time too, for some people or a doctor that was all the questions that we had today. Thank you so much for joining us. This was very informational. I think the sisters are going to love it and we can ask for more. My pleasure. Thank you so much for coming on. Oh,

it was my pleasure. All right. Take care of you guys. You too. All right. Thank you scissors for joining us today. This was an episode with Dr. Marc Ratner. And if you’re interested in purchasing a VESA tall, check out the link in the description where you can buy a basketball with our 15% off discount code. Thanks sisters.

Hope you enjoyed it. Take care. Bye bye. You enjoyed listening to this podcast. You have to come check out the sisterhood. It’s my monthly membership site, where sisters just like you are learning how to move through the stages of PCOS from Sage one cold and alone at the doctor’s office to stage five, nailing the PCs lifestyle, gluten and dairy free.

Get ready to finally feel in control of your body. Again.

Hey Cyster,
Join our newsletter

We got you! here’s some tips and tricks
on staying focused on your diagnosis.